![]() The aim of our study is to examine whether there is a difference between plasma ferritin levels identified as high and low in terms of laboratory reference range with different methods in our hormone and biochemistry moduleintegrated-systems (Roche Cobas 6000), and whether they can be used interchangeably. The fact that tests examined in hormone module and analyzed in biochemistry module provides advantages for the laboratory in terms of saving time and obtaining practical results. While plasma ferritin levels result in 9 minutes in biochemistry module (Cobas c501) with immunoturbidimetric method, they result in 18 minutes in hormone module (Cobas e601) with ECLIA method due to long incubation period. Hormone and biochemistry module-integratedsystems (Roche Cobas 6000) were used in our laboratories for measurement (or determination) of plasma ferritin. The one with the highest analytic specificity among these antibodies is liver ferritin. While anti-ferritin anti bodies (rabbit) are used in immunoturbidimetric method, antibodies against human liver, spleen and heart ferritins are used in immunoassay method. As these measurement methods used in clinical laboratories have different test principles, their reference ranges and measurement limits are also different from each other. These methods are immunoturbidimetric method and electrochemiluminescence (ECLIA) method. ![]() Although there are different methods for the measurement of plasma ferritin levels such as immunoturbidimetric method, electro chemiluminescence (ECLIA), Enzyme-Linked Immunosorbent Assay (ELISA), Radioimmunoassay (RIA), Chemiluminescence immunoassay (CLIA), the use of two methods in clinical laboratories stands out more. Additionally, high plasma ferritin levels reflect systemic inflammation as acute phase reactants. Plasma ferritin levels are sensitive parameters used for evaluating condition of iron in the body noninvasively and for diagnostic reagents of iron deficiency anemia. ![]()
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